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Help your patients create a new pathway to progress with deprexis®1

deprexis® is a digital therapy for depression that helps patients move forward in their own way by utilizing proven cognitive behavioral therapy (CBT)–based techniques.2

Interactive, personal, and clinically proven to reduce depressive symptoms, deprexis® uses artificial intelligence (AI)–guided technology to tailor what patients see based on their responses regarding their symptoms and challenges with depression.1-4

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How does deprexis® personalize the experience for your patients?

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Builds important skills

deprexis® helps each patient build the coping skills necessary to make progress with their depression5

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Always available

As a web-based program, deprexis® can be conveniently accessed 24/7 via smart device or computer anywhere internet is available6

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Creates personalized strategies

Starting with questions to the patient, deprexis® uses AI to personalize the chat and tailor the content based on their responses1

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Fits with any care plan

deprexis® offers the flexibility to fit with any existing treatment plan1,7-9

Studied across 11 trials with over 2800 patients, deprexis® was proven to help reduce symptoms of depression1,3,5,7-14

deprexis® was proven to help reducedepressive symptoms1

graph, deprexis had a 40.1 percent reduction in Quick Inventory of Depressive Symptomatology-Self-Report scores after 8 weeks, where other treatments had a 14.6% reduction.
QIDS-SR, Quick Inventory of Depressive Symptomatology–Self-Report.
deprexis® was associated with a significant reduction in depression symptoms after an 8-week treatment period compared to care-as-usual1

Care-as-usual was defined as any other treatment that patients were currently using.1

Symptom improvement as measured by the QIDS-SR score may have been related to mood, sleep, appetite, and energy levels.1,15

See the Full Study Design

To evaluate the effectiveness of deprexis® in improving depressive symptoms, 376 adults with at least moderate levels of depression (QIDS-SR ≥10) who were stable in depression were randomized to receive deprexis® + care-as-usual (n=285) or care-as-usual alone (n=91) for 12 weeks. Individuals with psychotic or substance abuse symptoms, bipolar disorder, or suicidal ideation were excluded.

deprexis® had a significant effect on
response to therapy1 (P<0.001)

Patients who added deprexis® to care-as-usual were 12x more
likely to respond to therapy after the 8-week treatment period
compared with patients maintained on care-as-usual1
Response to therapy was defined as ≥50% improvement in QIDS-SR from pretreatment to posttreatment.1

In a German study of 1013 patients, deprexis® users maintained a reduction in depressivesymptoms after 3 months13

Take a closer look at how deprexis® works

We’re here to support you and your patients with information about coverage,
reimbursement, additional resources, and much more

There when you need us

Our team is here to answer any questions regarding access to deprexis®, coverage information, or technical support.

References
  • 1. Beevers CG, Pearson R, Hoffman JS, et al. Effectiveness of an internet intervention (deprexis) for depression in a United States adult sample: a parallel-group pragmatic randomized controlled trial. J Consult Clin Psychol. 2017;85(4):367-380.
  • 2. American Psychological Association. What is cognitive behavioral therapy? Clinical practice guideline for the treatment of posttraumatic stress disorder. July 2017. Accessed March 11, 2021. https://apa.org/ptsd-guideline/patients-and-families/cognitive-behavioral.pdf
  • 3. Meyer B, Bierbrodt J, Schröder J, et al. Effects of an internet intervention (deprexis) on severe depression symptoms: randomized controlled trial. Internet Intervent. 2015;2(1):48-59.
  • 4. Driessen E, Hollon SD. Cognitive behavioral therapy for mood disorders: efficacy, moderators and mediators. Psychiatr Clin North Am. 2010;33(3):537-555.
  • 5. Meyer B, Berger T, Caspar F, et al. Effectiveness of a novel integrative online treatment for depression (deprexis): randomized controlled trial. J Med Internet Res. 2009;11(2):e15.
  • 6. Orexo acquires exclusive US rights to commercialize deprexis®, a world-leading digital therapy to help patients manage the symptoms of depression. News release. Orexo AB (publ.). May 11, 2020. Accessed March 11, 2021. https://orexo.com/investors/regulatory-press-releases/2020-05-11-orexo-acquires-exclusive-us-rights-to-commercialize-deprexis-a-world-leading-digital-therapy-to-help-patients-manage-the-symptoms-of-depression
  • 7. Berger T, Hämmerli K, Gubser N, et al. Internet-based treatment of depression: a randomized controlled trial comparing guided with unguided self-help. Cogn Behav Ther. 2011;40(4):251-266.
  • 8. Berger T, Krieger T, Sude K, et al. Evaluating an e-mental health program (“deprexis”) as adjunctive treatment tool in psychotherapy for depression: results of a pragmatic randomized controlled trial. J Affect Disord. 2018;227:455-462.
  • 9. Zwerenz R, Becker J, Knickenberg RJ, et al. Online self-help as an add-on to inpatient psychotherapy: efficacy of a new blended treatment approach. Psychother Psychosom. 2017;86(6):341-350.
  • 10. Moritz S, Schilling L, Hauschildt M, et al. A randomized controlled trial of internet-based therapy in depression. Behav Res Ther. 2012;50(7-8):513-521.
  • 11. Schröder J, Brückner K, Fischer A, et al. Efficacy of a psychological online intervention for depression in people with epilepsy: a randomized controlled trial. Epilepsia. 2014;55(12):2069-2076.
  • 12. Fischer A, Schröder J, Vettorazzi E, et al. An online programme to reduce depression in patients with multiple sclerosis: a randomised controlled trial. Lancet Psychiatry. 2015;2(3):217-223.
  • 13. Klein JP, Berger T, Schröder J, et al. Effects of a psychological internet intervention in the treatment of mild to moderate depressive symptoms: results of the EVIDENT study, a randomized controlled trial. Psychother Psychosom. 2016;85(4):218-228.
  • 14. Bücker L, Bierbrodt J, Hand I, et al. Effects of a depression-focused internet intervention in slot machine gamblers: a randomized controlled trial [published correction appears in PLoS One. Aug 23, 2018;13(8):e0203145]. PLoS One. 2018;13(6):e0198859.
  • 15. The Quick Inventory of Depressive Symptomatology (16-Item) (Self-Report) (QIDS-SR16). University of California, Los Angeles. Accessed March 11, 2021. http://narr.bmap.ucla.edu/docs/QIDS-SREnglish16item.pdf
  • 16. Zhang W-Y, Zhao Y-J, Zhang Y, et al. Psychometric properties of the Quick Inventory of Depressive Symptomatology–Self-Report (QIDS-SR) in depressed adolescents. Front Psychiatry. 2020;11:598609.

deprexis® is not a healthcare provider and does not provide medical advice, diagnosis, or standalone treatment. If patients need immediate medical attention, they should contact their healthcare provider or go to the closest emergency room.